mucin type ii
gastrin I
CAS: 10047-33-3;84082-64-4
Molecular Formula: C97H124N20O31S
mucin type ii - Names and Identifiers
| Name | gastrin I |
| Synonyms | GASTRIN I gastrin I mucin type ii Gastrin I Human GASTRIN-1 HUMAN Gastrin I human PYR-GPWLEEEEEAYGWMDF-NH2 PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 PYROGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 HUMAN PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM |
| CAS | 10047-33-3 84082-64-4 |
| EINECS | 233-157-0 |
| InChI | InChI=1/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133) |
mucin type ii - Physico-chemical Properties
| Molecular Formula | C97H124N20O31S |
| Molar Mass | 2098.2 |
| Density | 1.415±0.06 g/cm3(Predicted) |
| Boling Point | 2401.4±65.0 °C(Predicted) |
| Appearance | White powder |
| pKa | 4.19±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| MDL | MFCD00076500 |
| Physical and Chemical Properties | Pale yellow or pale gray powder, or tiny particles. The water swells into sticky slurry. Microlytic state, slightly peptone-like odor. Has a strong adhesion. |
| In vitro study | Gastrin I, human is the endogenous peptide produced in the stomach, and acts via cholecystokinin 2 (CCK2) receptor. |
| In vivo study | Gastrin I (1.5, 5, 15 and 45 nmol/kg, i.v.) increases pepsinogen and acid secretion in rats. |
mucin type ii - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-8-10-21 |
mucin type ii - Nature
Open Data Verified Data
- This product is light-yellow to light-gray-yellow powder or tiny particles, swellable to mucilage, micro-soluble state; Slightly peptone odor.
- This product is an anti-gastric acid glycoprotein extracted from porcine gastric mucosa. And acid for a long time, can be decomposed into various proteins and polysaccharide components, the polysaccharide component containing glucuronic acid, mannose, acetyl glucosamine and acetyl galactosamine. The total amount of amino hexose is 5% to 8%. The pH of the isoelectric point of the gastric membrane is 3. 3~5.
- The gastric membrane can form a membrane in the inner wall of the stomach, cover the ulcer surface, protect the ulcer wound, prevent the peptic erosion of the ulcer wound, prevent the ulcer attack, and reduce the pain of the patient. There is a weak anti-gastric acid effect.
Last Update：2024-01-02 23:10:35
mucin type ii - Preparation Method
Open Data Verified Data
- ethanol precipitation method (yield process)
- Fractional precipitation with acetone (co-production process)
3.5 of the gastric mucosa was crushed, and lOOkg of water and about 4L of hydrochloric acid were added to adjust the pH to 3 to, and the mixture was stirred at 40 to 45 ° C. For 3 to 4 hours. Impurities were removed by filtration. The extract was cooled to below 30 °c, and 16kg of chloroform was added thereto. The mixture was stirred well and allowed to stand at room temperature for more than 48 hours. The supernatant was sucked into a concentration tank and concentrated at 35 °c under reduced pressure to 1/3 of the original volume. The concentrate is then pre-cooled to below 5 °c, and cold acetone below 5 °c is slowly added with stirring to obtain a filamentous precipitate of pepsin. After standing for several hours, the gastrin was filtered out. The mother liquor can be treated to obtain pepsin. The obtained gastrin was washed twice with an appropriate amount of cold acetone, washed overnight with 70% acetone, and dried under vacuum at 70 ° C. To obtain a finished product. The yield was 1.2% ~ 1.4%.
Last Update：2022-01-01 11:13:44
mucin type ii - Application
Open Data Verified Data
-
li is used for hyperacidity and gastric and duodenal ulcers.
- usage and dosage of oral, 1~2G, 4 times a day.
- Specification: 50g.
Last Update：2025-08-19 16:24:40
mucin type ii - Safety
Open Data Verified Data
It was kept in the cold and dark place under closed storage.
Last Update：2022-01-01 11:13:44
mucin type ii - Reference Information
| overview | gastric membrane element, which means gastric mucosa regeneration. The gastrin extracted from the gastric mucosa of pigs is white to yellow-white powder or yellow-brown particles, with a peptone smell, a slightly salty taste, and the water rises into a slime, which is slightly soluble, and the aqueous solution is gray or milky white. It precipitates when it is weak acid, does not solidify when it is heated, and can be precipitated by more than 60% ethanol or acetone in the solution. With acid for a long time, can be decomposed into a variety of protein and polysaccharide components, the polysaccharide components contain glucuronic acid, mannose, acetylglucosamine and acetylgalactose, the total amount of hexosamine is 5~8%,PI3.3~5. my country is extremely rich in raw materials for pig stomach, but the process of extracting gastrin from pig gastric mucosa is relatively backward. In China, it is mainly produced according to the process route of gastric mucosal digestion, trichloromethane or ether degreasing, acetone precipitation, and drying. The process takes a long time and the yield of gastrin is low, only about 1.5%; foreign countries adopt pH6.5 NaH3PO4, EDTA, NEM and guanidine hydrochloride buffer as the extract, after high-speed centrifugation, dialysis, and equal density gradient centrifugation, the process is complex, the production cost is high, the production cycle is long, the ethanol extraction method is used to improve the yield of gastric membrane, the production cost is low, and the extraction ethanol concentration is strictly controlled, Processing time and temperature to improve product quality. |
| application | gastric membrane is a mucin prepared by digestion and extraction of pig gastric mucous membrane. it has anti-pepsin decomposition and weak anti-acid effect, can form a membrane in the stomach, cover the ulcer surface, reduce the stimulation of gastric acid, and is conducive to the healing of the ulcer surface, it can also reduce the pain of patients. Gastrin can activate the regenerative DNA replication chain of gastric mucosal cells, so that the gastric mucosa can quickly generate new tissues. In addition, it has anti-pepsin decomposition and weak antacid effects, forming a membrane in the stomach, covering the ulcer surface, and reducing the stimulation of gastric acid. Conducive to the healing of the ulcer surface; clinically used to treat gastric, duodenal ulcer and hyperacidity. |
| biological activity | Gastrin I, human is an endogenous peptide produced in the stomach, which increases the secretion of gastric acid through the CCK2 receptor. |
| target | CCK2 receptor |
| in vitro study | Gastrin I, human is the endogenous peptide produced in the stomach, and acts via cholecystokinin 2 (CCK2) receptor. |
| in vivo study | Gastrin I (1.5, 5, 15 and 45 nmol/kg, I. v.) increases pepsinogen and acid secretion in rats. |
| chemical properties | light yellow or light gray powder, or tiny particles. The water swells into sticky slurry. Microlytic state, slightly peptone-like odor. Has a strong adhesion. |
| use | the product is adhered to the inner wall of the stomach after taking it, forming a protective film on the ulcer wound surface, reducing the stimulation of gastric acid on the ulcer surface, preventing it from being corroded by gastric acid and gastric enzymes, thus achieving the purpose of healing the wound. Can be used for stomach, duodenal ulcer and hyperacidity. |
| production method | gastric membrane sediment obtained by separating pepsin production is extruded into water, tore and washed fully with 2 times of cold acetone, let stand for 24 hours, and pour out acetone. Wash with cold acetone once, pour out acetone after 24 hours, fully stir with 2 times the amount of fresh acetone, soak for 48 hours, pour out acetone, squeeze dry, and obtain gastric membrane hormone wet product. Dry the wet product with water content not exceeding 5%, crush it with a ball mill and sift it with 60 mesh to obtain gastrin. For gastric viscosity meter, the total yield is 1.2-1.5%. |
Last Update：2024-04-09 20:52:54
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